Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study.
Identifieur interne : 000093 ( Main/Exploration ); précédent : 000092; suivant : 000094Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study.
Auteurs : María Luz García-García [Espagne] ; Cristina Calvo [Espagne, Italie] ; Cristina Rey [Espagne] ; Beatriz Díaz [Espagne] ; Maria Del Mar Molinero [Espagne] ; Francisco Pozo [Espagne] ; Inmaculada Casas [Espagne]Source :
- PloS one [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- isolement et purification : Metapneumovirus.
- virologie : Infections de l'appareil respiratoire.
- Adolescent, Enfant, Enfant d'âge préscolaire, Espagne, Femelle, Hospitalisation, Humains, Mâle, Nourrisson, Études prospectives.
English descriptors
- KwdEn :
- MESH :
- isolation & purification : Metapneumovirus.
- virology : Respiratory Tract Infections.
- Adolescent, Child, Child, Preschool, Female, Hospitalization, Humans, Infant, Male, Prospective Studies, Spain.
Abstract
BACKGROUND
Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections in children under five years. Our objectives were to estimate the relative contribution of HMPV to hospitalization in children with acute respiratory infection, to define the clinical and epidemiological features of HMPV single and multiple infections, and to compare HMPV infections with respiratory syncytial virus (HRSV), rhinovirus (HRV), adenovirus and human bocavirus infections in the same population.
METHODS AND FINDINGS
A prospective study performed on all children less than 14 years of age with a respiratory tract disease admitted to a secondary hospital between September 2005- June 2014. Clinical characteristics of patients were analyzed. Nasopharyngeal aspirate was taken at admission for viral study with polymerase chain reaction for 16 respiratory viruses. A total of 3,906 children were included. At least one respiratory virus was detected in 75.2% of them. The most common identified virus was HRSV, followed by HRV. HMPV was detected in 214 cases (5.5%); 133 (62%) were single infections and the remaining were detected in coinfection with other viruses. 90.7% cases were detected between February and May. Children's mean age was 13.83 ± 18 months. Fever was frequent (69%), and bronchiolitis (27%), and recurrent wheezing (63%) were the main clinical diagnosis. Hypoxia was present in 65% of the patients and 47% of them had an infiltrate in X-ray. Only 6 (2.8%) children were admitted to the intensive care unit. Only the duration of the hospitalization was different, being longer in the coinfections group (p <0.05). There were many differences in seasonality and clinical characteristics between HMPV and other respiratory viruses being more similar to HRSV.
CONCLUSIONS
HMPV infections accounted for 5.5% of total viral infections in hospitalized children. The clinical characteristics were similar to HRSV infections, but seasonality and clinical data were different from other viral infections.
DOI: 10.1371/journal.pone.0173504
PubMed: 28301570
PubMed Central: PMC5354294
Affiliations:
Links toward previous steps (curation, corpus...)
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Madrid</region></placeName></affiliation></author><author><name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name><affiliation wicri:level="3"><nlm:affiliation>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name><affiliation wicri:level="3"><nlm:affiliation>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Respiratory Viruses and Influenza Unit, National Microbiology Center 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study.</title><author><name sortKey="Garcia Garcia, Maria Luz" sort="Garcia Garcia, Maria Luz" uniqKey="Garcia Garcia M" first="María Luz" last="García-García">María Luz García-García</name><affiliation wicri:level="3"><nlm:affiliation>Pediatrics Department, Severo Ochoa Hospital, Leganés, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pediatrics Department, Severo Ochoa Hospital, Leganés, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University Alfonso X el Sabio, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University Alfonso X el Sabio, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Calvo, Cristina" sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name><affiliation wicri:level="3"><nlm:affiliation>Pediatrics Department, Severo Ochoa Hospital, Leganés, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pediatrics Department, Severo Ochoa Hospital, Leganés, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University Alfonso X el Sabio, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University Alfonso X el Sabio, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>TEDDY Network Member (European Network of Excellence for Pediatric Clinical Research, Bari, Italy).</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Italie</country><wicri:regionArea>TEDDY Network Member (European Network of Excellence for Pediatric Clinical Research, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Rey, Cristina" sort="Rey, Cristina" uniqKey="Rey C" first="Cristina" last="Rey">Cristina Rey</name><affiliation wicri:level="3"><nlm:affiliation>University Alfonso X el Sabio, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University Alfonso X el Sabio, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Diaz, Beatriz" sort="Diaz, Beatriz" uniqKey="Diaz B" first="Beatriz" last="Díaz">Beatriz Díaz</name><affiliation wicri:level="3"><nlm:affiliation>University Alfonso X el Sabio, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University Alfonso X el Sabio, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Molinero, Maria Del Mar" sort="Molinero, Maria Del Mar" uniqKey="Molinero M" first="Maria Del Mar" last="Molinero">Maria Del Mar Molinero</name><affiliation wicri:level="3"><nlm:affiliation>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name><affiliation wicri:level="3"><nlm:affiliation>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Casas, Inmaculada" sort="Casas, Inmaculada" uniqKey="Casas I" first="Inmaculada" last="Casas">Inmaculada Casas</name><affiliation wicri:level="3"><nlm:affiliation>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Female (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Male (MeSH)</term><term>Metapneumovirus (isolation & purification)</term><term>Prospective Studies (MeSH)</term><term>Respiratory Tract Infections (virology)</term><term>Spain (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Espagne (MeSH)</term><term>Femelle (MeSH)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Metapneumovirus (isolement et purification)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Metapneumovirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Metapneumovirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Infant</term><term>Male</term><term>Prospective Studies</term><term>Spain</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Espagne</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections in children under five years. Our objectives were to estimate the relative contribution of HMPV to hospitalization in children with acute respiratory infection, to define the clinical and epidemiological features of HMPV single and multiple infections, and to compare HMPV infections with respiratory syncytial virus (HRSV), rhinovirus (HRV), adenovirus and human bocavirus infections in the same population.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS AND FINDINGS</b></p><p>A prospective study performed on all children less than 14 years of age with a respiratory tract disease admitted to a secondary hospital between September 2005- June 2014. Clinical characteristics of patients were analyzed. Nasopharyngeal aspirate was taken at admission for viral study with polymerase chain reaction for 16 respiratory viruses. A total of 3,906 children were included. At least one respiratory virus was detected in 75.2% of them. The most common identified virus was HRSV, followed by HRV. HMPV was detected in 214 cases (5.5%); 133 (62%) were single infections and the remaining were detected in coinfection with other viruses. 90.7% cases were detected between February and May. Children's mean age was 13.83 ± 18 months. Fever was frequent (69%), and bronchiolitis (27%), and recurrent wheezing (63%) were the main clinical diagnosis. Hypoxia was present in 65% of the patients and 47% of them had an infiltrate in X-ray. Only 6 (2.8%) children were admitted to the intensive care unit. Only the duration of the hospitalization was different, being longer in the coinfections group (p <0.05). There were many differences in seasonality and clinical characteristics between HMPV and other respiratory viruses being more similar to HRSV.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>HMPV infections accounted for 5.5% of total viral infections in hospitalized children. The clinical characteristics were similar to HRSV infections, but seasonality and clinical data were different from other viral infections.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28301570</PMID><DateCompleted><Year>2017</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2019</Year><Month>02</Month><Day>08</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>3</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study.</ArticleTitle><Pagination><MedlinePgn>e0173504</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0173504</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections in children under five years. Our objectives were to estimate the relative contribution of HMPV to hospitalization in children with acute respiratory infection, to define the clinical and epidemiological features of HMPV single and multiple infections, and to compare HMPV infections with respiratory syncytial virus (HRSV), rhinovirus (HRV), adenovirus and human bocavirus infections in the same population.</AbstractText><AbstractText Label="METHODS AND FINDINGS" NlmCategory="RESULTS">A prospective study performed on all children less than 14 years of age with a respiratory tract disease admitted to a secondary hospital between September 2005- June 2014. Clinical characteristics of patients were analyzed. Nasopharyngeal aspirate was taken at admission for viral study with polymerase chain reaction for 16 respiratory viruses. A total of 3,906 children were included. At least one respiratory virus was detected in 75.2% of them. The most common identified virus was HRSV, followed by HRV. HMPV was detected in 214 cases (5.5%); 133 (62%) were single infections and the remaining were detected in coinfection with other viruses. 90.7% cases were detected between February and May. Children's mean age was 13.83 ± 18 months. Fever was frequent (69%), and bronchiolitis (27%), and recurrent wheezing (63%) were the main clinical diagnosis. Hypoxia was present in 65% of the patients and 47% of them had an infiltrate in X-ray. Only 6 (2.8%) children were admitted to the intensive care unit. Only the duration of the hospitalization was different, being longer in the coinfections group (p <0.05). There were many differences in seasonality and clinical characteristics between HMPV and other respiratory viruses being more similar to HRSV.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">HMPV infections accounted for 5.5% of total viral infections in hospitalized children. The clinical characteristics were similar to HRSV infections, but seasonality and clinical data were different from other viral infections.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>García-García</LastName><ForeName>María Luz</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Pediatrics Department, Severo Ochoa Hospital, Leganés, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University Alfonso X el Sabio, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6503-3423</Identifier><AffiliationInfo><Affiliation>Pediatrics Department, Severo Ochoa Hospital, Leganés, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University Alfonso X el Sabio, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>TEDDY Network Member (European Network of Excellence for Pediatric Clinical Research, Bari, Italy).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rey</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University Alfonso X el Sabio, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Díaz</LastName><ForeName>Beatriz</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>University Alfonso X el Sabio, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molinero</LastName><ForeName>Maria Del Mar</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pozo</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casas</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Traslational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Respiratory Viruses and Influenza Unit, National Microbiology Center (ISCIII), Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" 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MajorTopicYN="N">Spain</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>12</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28301570</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0173504</ArticleId><ArticleId IdType="pii">PONE-D-16-48905</ArticleId><ArticleId 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sort="Calvo, Cristina" uniqKey="Calvo C" first="Cristina" last="Calvo">Cristina Calvo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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